Metronidazole has proven evidence of mutagenic activity in many in vitro bacterial assay units. In addition, a dose-reaction rise in the frequency of micronuclei was observed in mice right after intraperitoneal injections and an increase in chromosome aberrations have already been documented in sufferers with Crohn's sickness who were being addressed with 200-1200 mg/day of metronidazole for one to 24 months.
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Instantly reevaluate METROGEL therapy if abnormal neurologic symptoms surface. Administer metronidazole with caution to individuals with central nervous program disorders.
Oral metronidazole continues to be described to potentiate the anticoagulant outcome of warfarin and also other coumarin anti‑coagulants, causing a prolongation of prothrombin time.
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